Guajillo Chili Hot Sauce

This easy recipe for guajillo chili hot sauce is spicy, smoky and rich. It makes a wonderful base for enchilada sauce and tastes amazing on a taco! Great for Cinco de Mayo!

This post may contain affiliate links.

YouTube video

This morning, not only do I have a killer recipe for hot sauce, I also have some killer news to share! 

I'm beyond excited to announce that I'm going to be doing a little cooking demonstration on the Today Show next week! I'll be on Thursday, April 28th between 8am and 9am (EST), so mark your calendars, set your alarm clocks, and check your local listings (the Today Show is on NBC). I'll be whipping up a favorite family recipe called Spiedini that ironically, I posted exactly one year ago. I hope you'll tune in and watch me (hopefully) not act like a total goober on screen.

Now, on to the hot sauce. It's hot! But not too hot. It's inspired by a place called Pancho, which is a little taco joint that sits next to the famous White House Sub Shop in Atlantic City. Any time of day you'll find people lined up outside of White House, waiting to taste one of their amazing, old school sandwiches. But what they don't know is that the tiny little unassuming spot next door has the most fire tacos they'll ever try. (Plus, no line!)

Fire has a double meaning in that statement. They're fire in the figurative sense, but also quite literally. The menu is small and totally made from scratch, right down to the fresh corn tortillas that you can watch them make to order. Everything is served up with bottles of their insanely spicy housemade green and red hot sauces. Being the glutton for punishment that I am, I drown my tacos in both sauces until I can't feel my face. But I love it.

Last year I made a version of the green stuff, but this time around I attempted the red. I have no idea what kind of chiles they use (they won't tell me, of course I tried asking), but after making this, I'm pretty sure it's not guajillos. This version is less spicy and has a tangy, fruity quality to it. It's really delicious on tacos and any other Mexican food, or used as a robust sauce for meats and fish.

If you can't find guajillos or want your sauce to be spicier, experiment with your favorite dried chiles instead. Use the method in the video, and whatever you make is bound to be fire... both literally and figuratively.

Guajillo Chile Hot Sauce (Video!)

One Year Ago: Spiedini Alla Siciliana

Want to Save This Recipe?

Enter your email & I'll send it to your inbox.

Save Post

By submitting this form, you consent to receive emails from Coley Cooks.

Close up of a yellow bowl filled with homemade guajillo chili hot sauce.
Print Pin

Guajillo Chili Hot Sauce

This easy recipe for guajillo chili hot sauce is spicy, smoky and rich. It makes a wonderful base for enchilada sauce and tastes amazing on a taco! Great for Cinco de Mayo!
Prep Time: 10 minutes
Cook Time: 10 minutes
Total Time: 20 minutes
Servings: 3 cups
Calories: 70kcal


  • 15 Guajillo Chilis stems and seeds removed*
  • 2 cups water more as needed
  • 5 cloves garlic unpeeled
  • ¼ small white onion
  • 2 tablespoons to ¼ cup white distilled vinegar to taste
  • 1-2 teaspoons kosher salt to taste


  1. Heat a large cast iron skillet or comal over very high heat. Once the pan is smoking hot, place the chilis on in a single layer (work in batches) and toast for a few seconds on each side. The chilis should turn bright red and become pliable, but be careful not to let them burn. It can happen in a matter of seconds and will turn the chilis bitter.
  2. Transfer the chilis to a bowl and cover with about 2 cups of boiling water, or more as needed. Set aside and allow to soak for at least ten minutes. While the chilis are soaking, place the garlic cloves and whole piece of onion on the hot skillet, and turn until charred on all sides, about 8 minutes. Allow the garlic to cool, then remove the skins. Transfer the garlic, onion, chilis, about half of the water, vinegar and salt to a blender.
  3. Blend on high until nice and smooth, then taste and add more water, vinegar and salt as needed to adjust the seasoning and thickness. Continue blending until totally smooth. Transfer to a bowl or squeeze bottle and keep refrigerated** for up to 2 months.


  • *Feel free to substitute your favorite dried chili, or a combination of a few different ones. Choose dried chilis that are slightly pliable and not brittle, an indicator of their freshness. Removing the seeds will result in a less spicy, smoother sauce. Leave the seeds in for added heat and texture.
  • **For longer storage, seal in an airtight container and freeze for up to 6 months.


Calories: 70kcal | Carbohydrates: 15g | Protein: 2g | Fat: 1g | Saturated Fat: 0.1g | Polyunsaturated Fat: 1g | Monounsaturated Fat: 0.1g | Sodium: 800mg | Potassium: 361mg | Fiber: 5g | Sugar: 8g | Vitamin A: 4636IU | Vitamin C: 8mg | Calcium: 25mg | Iron: 1mg

GUAJILLO CHILI HOT SAUCE | Easy Mexican dried chili hot sauce recipe perfect for enchilada sauce and tastes amazing on tacos! Great Cinco de Mayo recipe! Taco ideas. Mexican recipes. #vegan #glutenfree #paleo |

4.67 from 3 votes (1 rating without comment)

Did you make this recipe? Please leave a ⭐ rating and review!

Your email address will not be published. Required fields are marked *

Recipe Rating

This site uses Akismet to reduce spam. Learn how your comment data is processed.


  1. 5 stars
    Ahh! Congratulations on The Today Show, that's so exciting! You're gonna crush it 🙂 Also, this sauce looks amazeballs.