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Guajillo Chili Hot Sauce

  • Author: Nicole Gaffney (
  • Prep Time: 10 minutes
  • Cook Time: 10 minutes
  • Total Time: 20 minutes
  • Yield: 3 1/2 cups 1x
  • Category: condiment
  • Method: stovetop
  • Cuisine: Mexican


This easy recipe for guajillo chili hot sauce is spicy, smoky and rich. It makes a wonderful base for enchilada sauce and tastes amazing on a taco! Great for Cinco de Mayo!


  • 15 Guajillo Chilis, stems and seeds removed*
  • 2 cups water, more as needed
  • 5 cloves garlic, unpeeled
  • 1/4 small white onion
  • 2 tablespoons to 1/4 cup white distilled vinegar, to taste
  • 12 teaspoons kosher salt, to taste


  1. Heat a large cast iron skillet or comal over very high heat. Once the pan is smoking hot, place the chilis on in a single layer (work in batches) and toast for a few seconds on each side. The chilis should turn bright red and become pliable, but be careful not to let them burn. It can happen in a matter of seconds and will turn the chilis bitter.
  2. Transfer the chilis to a bowl and cover with about 2 cups of boiling water, or more as needed. Set aside and allow to soak for at least ten minutes. While the chilis are soaking, place the garlic cloves and whole piece of onion on the hot skillet, and turn until charred on all sides, about 8 minutes. Allow the garlic to cool, then remove the skins. Transfer the garlic, onion, chilis, about half of the water, vinegar and salt to a blender.
  3. Blend on high until nice and smooth, then taste and add more water, vinegar and salt as needed to adjust the seasoning and thickness. Continue blending until totally smooth. Transfer to a bowl or squeeze bottle and keep refrigerated** for up to 2 months.


  • *Feel free to substitute your favorite dried chili, or a combination of a few different ones. Choose dried chilis that are slightly pliable and not brittle, an indicator of their freshness. Removing the seeds will result in a less spicy, smoother sauce. Leave the seeds in for added heat and texture.
  • **For longer storage, seal in an airtight container and freeze for up to 6 months.

Keywords: hot sauce, hot chili sauce, homemade hot sauce, guajillo